Ami Aronheim

Prof. Ami Aronheim

Department of Molecular genetics Medicine
Site

Research Interests:

Signal transduction and control of gene expression

Short Synopsis:

cardiac hypertrophy, type 2 diabetes induced cardiomyopathy, host response to cancer,   JNK scaffold protein.

 

Cohen-Katsenelson K*., Wasserman, T*., Khateb, S., Whitmarsh, A.J. and  Aronheim, A. “Docking interactions of the JNK scaffold protein WDR62” Biochemical J. 439, 381-390 (2011).

Darlyuk-Saadon, I., Weidenfeld-Baranboim, K., Yokoyama, K.K., Hai, T. and Aronheim, A. “The bZIP repressor proteins, c-Jun Dimerization Protein 2 and Activating Transcription Factor 3, recruit multiple HDAC members to the ATF3 promoter” BBA Gene Regulatory Mechanisms 1819, 1142-1153 (2012).

Cohen-Katsenelson, K*., Wasserman, T*., Darlyuk-Saadon, I*, Rabner, A., Glaser, F., and Aronheim, A. “Identification and analysis of a novel dimerization domain shared by various members of JNK scaffold proteins” J. Biol. Chem. 288, 7294-7304 (2013).

Hill, C., Wurfel, A., Heger, J., Meyering, B., Schluter, K.-D,  Weber, M., Ferdinandy, P., Aronheim, A., Schulz, R., and Euler, G. “Inhibition of AP-1 signaling by JDP2 overexpression protects cardiomyocytes against hypertrophy and apoptosis induction” Cardiovascular Research 2013; doi: 10.1093/cvr/cvt094.

Koren, L., Elhanani, O., Kehat, I., Hai, T. and Aronheim, A. “Adult cardiac expression of the activating transcription factor 3, ATF3, promotes ventricular hypertrophy” PLoS ONE 8(7): e68396. doi:10.1371/journal.pone.0068396 (2013).