Brain Systems Organization and Neurodegeneration
Our lab uses functional magnetic resonance imaging (fMRI) combined with optogenetic tools and animal models to investigate the dynamic interaction between neural circuits. We seek to understand how these systems-level dynamics give rise to various aspects of brain function and behavior in health and disease. Whole-brain fMRI combined with single cell electrophysiology, the lab is able to study mechanisms
governing neural dynamics at the level of the microcircuit and across brain regions.
Kahn I. & Shohamy D. (2013). Intrinsic Connectivity between the Hippocampus, Nucleus Accumbens and Ventral Tegmental Area in Humans. Hippocampus 23:187-192.
Kahn I.*, Knoblich U.*, Desai M., Bernstein J., Graybiel A.M., Boyden E.S., Buckner R.L., & Moore C.I. (2013). Optogenetic Drive of Neocortical Pyramidal Neurons Generates fMRI Signals That Are Correlated with Spiking Activity. Brain Research 1511:33-45.*equal authorship
Kahn I.*, Desai M.*, Knoblich U.*, Bernstein J., Henninger M., Graybiel A. M., Boyden E.S., Buckner R.L., & Moore C.I. (2011). Characterization of the Functional MRI Response Temporal Linearity via Optical Control of Neocortical Pyramidal Neurons. Journal of Neuroscience 31:15086-15091. *equal authorship
Kahn I., Andrews-Hanna J. R., Vincent J. L., Snyder A. Z., & Buckner R. L. (2008). Distinct cortical anatomy linked to subregions of the medial temporal lobe revealed by intrinsic functional connectivity. Journal of Neurophysiology 100(1):129-139.
Kahn I., Davachi L., & Wagner A. D. (2004). Functional-neuroanatomic correlates of recollection: Implications for models of recognition memory. Journal of Neuroscience 24:4172-4180.