Professor Noam E Ziv

Research Interests:

Synaptic Dynamics and Tenacity

Short Synopsis:

The Ziv lab uses long-term imaging and multielectrode array recordings to study the remodeling dynamics of CNS synapses at both the population and individual synapse level. The focus of these studies is to determine the degree to which synaptic remodeling and tenacity depend on activity, specific molecules, and stochastic processes acting at many time scales.
Collaborations outside the Technion
Craig Garner, Stanford; Eckart Gundelfinger,  Michael Kreutz, Daniela Dieterich, IfN, Magdeburg; Susanne Schoch, Inst. of Neuropathology, Bonn; Nils Brose, MPI Goettingen; Kobi Rosenblum, Haifa

Tsuriel, S., Fisher, A. Wittenmayer, N., Dresbach, T., Garner, C.C., Ziv., N.E. (2009) Exchange and redistribution dynamics of the cytoskeleton of the active zone molecule Bassoon.  Journal of Neuroscience 29, 351-358.
Minerbi, A., Kahana, R., Goldfeld, L., Kaufman, M., Marom, S., Ziv, N.E. (2009) Long-term Relationships between Synaptic Tenacity, Synaptic Remodeling and Network Activity. PLoS Biology 7(6): e1000136. doi:10.1371/journal.pbio.1000136..
Fisher-Lavie. A., Zeidan, A., Stern, M., Garner, C.C., Ziv, N.E. (2011) Use dependence of presynaptic tenacity. Journal of Neuroscience.  31, 16770-16780.
Zeidan, A., Ziv, N.E. (2012) Neuroligin-1 loss is associated with reduced tenacity of excitatory synapses. PLoS One. 7(7):e42314.
Kaufman, M., Corner, M.A., Ziv, N.E. (2012) Long-term relationships between cholinergic tone, synchronous bursting and synaptic remodeling. PLoS One. 7(7):e40980.
Cohen, L.D., Zuchman, R., Sorokina, O., Müller, A., Dieterich, D.C., Armstrong, J.D., Ziv, T., Ziv, N.E. (2013) Metabolic turnover of synaptic proteins: kinetics, interdependencies and implications for synaptic maintenance. PLoS One. 8(5):e63191.
Fisher-Lavie, A., Ziv, N.E. (2013) Matching dynamics of presynaptic and postsynaptic scaffolds.  Journal of Neuroscience 33, 13094-13100.