Molecular Immunology, Cancer Immunotherapy, Antibody engineering, Tumor Immunology
Our lab focuses on molecular immunology addressing basic and transnational research on cancer, autoimmunity and inflammation. Using molecular tools we ask basic questions related to the control and function of immune effector cells (mainly T cells) on malignant cells. We also apply translational research attempting to develop new approach for cancer immunotherapy as well as novel molecules that can block auto-reactive T cells in autoimmunity and inflammation. We used recombinant antibody technology to develop novel recombinant antibodies and are using systems biology computational tools to understand the complex functions of immune cell populations and their reactivates against tumor cells. Our lab employs state-of-the-art multiple research approaches and strategies at the cutting edge of molecular approaches such as recombinant DNA technology, recombinant antibodies, phage display, cellular immunology, systems approaches, gene expression analysis, proteomic analysis, multi-parameter flow cytometry and more. In addition we have employing interdisciplinary approaches to merge molecular biology with nanoelectronics through the generation of biological molecules that can sense physical properties. These projects are carried as collaborations with Prof. Uri Sivan from the physics department.